abstract：:Opioid receptors play an important role in modulation of hyperalgesia in inflamed tissues, but chronic morphine application induces such side effects as tolerance. There is near communications between cytokines and mu opioid receptor expression. This study was aimed to assess the role of serum IL-10 in morphine tolera...

journal_title：Journal of physiology and biochemistry

authors： Zaringhalam J,Hormozi A,Tekieh E,Razavi J,Khanmohammad R,Golabi S

更新日期：2014-06-01 00:00:00

abstract：:Pouteria campechiana (Kunth) Baehni. is used as a remedy for coronary trouble, liver disorders, epilepsy, skin disease, and ulcer. Therefore, the present study aims to investigate the antioxidant and hepatoprotective effect of polyphenolic-rich P. campechiana fruit extract against acetaminophen-intoxicated rats. Total...

journal_title：Journal of physiology and biochemistry

authors： Aseervatham GS,Sivasudha T,Sasikumar JM,Christabel PH,Jeyadevi R,Ananth DA

更新日期：2014-03-01 00:00:00

abstract：:Reduced nitric oxide availability and a heterogeneous pattern of nitric oxide synthase activity in some tissues have been reported in hypothyroidism. This study aimed at determining the effects of oral nitrate and L-arginine administration on serum, heart, and aorta nitric oxide metabolite concentrations in fetal hypo...

journal_title：Journal of physiology and biochemistry

authors： Ghasemi A,Mehrazin F,Zahediasl S

更新日期：2013-12-01 00:00:00

abstract：:High fat diet (HFD) is a common cause of metabolic syndrome and type 2 diabetes mellitus. Published data showed that HFD and subsequent dyslipidemia are major triggers for oxidative stress. Forty-eight male Sprague-Dawley rats, weighing 170-200 g, were divided into six groups: control, control with vitamin E (100 mg/k...

journal_title：Journal of physiology and biochemistry

authors： Abbas AM,Sakr HF

更新日期：2013-12-01 00:00:00

abstract：:In the present work, we have evaluated the effect of an acute addition of melatonin on cholecystokinin octapeptide (CCK-8)-evoked Ca(2+) signals and amylase secretion in mouse pancreatic acinar cells. For this purpose, freshly isolated mouse pancreatic acinar cells were loaded with fura-2 to study intracellular free C...

journal_title：Journal of physiology and biochemistry

authors： Santofimia-Castaño P,Ruy DC,Salido GM,González A

更新日期：2013-12-01 00:00:00

abstract：:Activation of 5' adenosine monophosphate-activated protein kinase (AMPK) with aminoimidazole carboxamide ribonucleotide (AICAR) increases skeletal muscle glucose uptake and fatty acid oxidation. The purpose of these experiments was to utilize AICAR to enhance palmitate consumption by mitochondria in cultured skeletal ...

journal_title：Journal of physiology and biochemistry

authors： Spangenburg EE,Jackson KC,Schuh RA

更新日期：2013-12-01 00:00:00

abstract：:The question as to whether A3 adenosine receptor (A3AR) agonists, N (6)-(3-iodobenzyl)-adenosine-5'-N- methyluronamide (IB-MECA) and 2-chloro-N (6)-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA), could exert cytotoxic effects at high concentrations with or without the involvement of A3AR has been a controv...

journal_title：Journal of physiology and biochemistry

authors： Mlejnek P,Dolezel P,Frydrych I

更新日期：2013-09-01 00:00:00

abstract：:In response to stress, the hypothalamus releases cortiticotropin releasing hormone (CRH) that travels to the anterior pituitary, where it stimulates the release of adrenocorticotropic hormone (ACTH). ACTH travels to the adrenal cortex, where it stimulates the release of cortisol and other steroids that liberate energy...

journal_title：Journal of physiology and biochemistry

authors： Thomson M

更新日期：2013-09-01 00:00:00

abstract：:The present review aims to illustrate current knowledge about the efficacy of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) in treating/preventing several metabolic pathologies. We reviewed systematically the published evidence on the effectiveness of n-3 LC-PUFAs fish consumption or n-3 LC-PUFAs suppl...

journal_title：Journal of physiology and biochemistry

authors： Lorente-Cebrián S,Costa AG,Navas-Carretero S,Zabala M,Martínez JA,Moreno-Aliaga MJ

更新日期：2013-09-01 00:00:00

abstract：:The purpose of this study was to evaluate the effect of pomegranate (Punica granatum) in inhibiting and reversing the nephrotoxicity of carbon tetrachloride, a potent oxidative stress inducer which induces cellular kidney damage. Rats were intraperitoneally injected with carbon tetrachloride (2 mL/kg body weight) whic...

journal_title：Journal of physiology and biochemistry

authors： Abdel Moneim AE,El-Khadragy MF

更新日期：2013-09-01 00:00:00

abstract：:The effect of long-lasting in vivo restriction of nitric oxide (NO) bioavailability on cardiac and renal P-type ATPases critical for intracellular ion homeostasis is controversial. Previous work has shown in eNOS knockout (eNOS(-/-)) mice hearts that Na(+)/K(+)- and Ca(2+)-ATPase activities were depressed but the unde...

journal_title：Journal of physiology and biochemistry

authors： Rezende DC,Pôças ES,Muzi-Filho H,Cunha VM,Caricati-Neto A,Jurkiewicz A,Noël F,Quintas LE

更新日期：2013-06-01 00:00:00

abstract：:Regular physical exercise is recognized as a nonpharmacological therapeutic strategy in the treatment of metabolic syndrome, and has been proposed for improving obesity, diabetic status, insulin resistance, and immune response. The aim of the present study was to evaluate the effect of a regular exercise program (trea...

journal_title：Journal of physiology and biochemistry

authors： Martín-Cordero L,García JJ,Hinchado MD,Bote E,Ortega E

更新日期：2013-03-01 00:00:00

abstract：:Serotonin (5-HT) is one of the regulators of feeding in humans. Drugs acting on the serotoninergic system are used to treat bulimia nervosa and to enhance the effect of hypocaloric diets in overweight subjects. They act rapidly to normalise feeding when used to treat eating-related problems. To explore the role of the...

journal_title：Journal of physiology and biochemistry

authors： Lauzurica N,García-García L,Fuentes JA,Delgado M

更新日期：2013-03-01 00:00:00

abstract：:There have been numerous reports that infusion of either natural bile or bile salts into the duodenum evokes a rapid increase in pancreatic secretion through the release of the hormone secretin from the duodenal mucosa. We have extended this observation by the demonstration of an additional late increase in secretion ...

journal_title：Journal of physiology and biochemistry

authors： Morrison JD

更新日期：2012-12-01 00:00:00

abstract：:Oxidative stress has been shown to induce apoptosis in cancer cells. Therefore, one might suspect that antioxidants may inhibit reactive oxygen species (ROS) and prevent apoptosis of cancer cells. No study has been carried out so far to elucidate the effects of N-acetylcysteine (NAC) on bleomycin-induced apoptosis in ...

journal_title：Journal of physiology and biochemistry

authors： Cort A,Timur M,Dursun E,Kucuksayan E,Aslan M,Ozben T

更新日期：2012-12-01 00:00:00

abstract：:MicroRNAs (miRNAs), a class of small, single-stranded endogenous RNAs, act as post-transcriptional regulators of gene expression. The ability of one single miRNA regulating multiple functionally related mRNAs makes it a new potential candidate for cancer gene therapy. Let-7s miRNAs have been demonstrated as tumor-supp...

journal_title：Journal of physiology and biochemistry

authors： Wang QZ,Lv YH,Gong YH,Li ZF,Xu W,Diao Y,Xu R

更新日期：2012-03-01 00:00:00

abstract：:Vitamin A or retinol plays a major role in the regulation of cellular homeostasis. Retinyl palmitate remains the main chemical form of vitamin A storage and is mainly located in hepatic stellate cells (HSCs) in lipid droplets resembling those found in adipose cells. White adipose tissue (WAT), is essentially involved ...

journal_title：Journal of physiology and biochemistry

authors： Sauvant P,Cansell M,Atgié C

更新日期：2011-09-01 00:00:00

abstract：:Thrombospondin 1 (TSP-1), an antiangiogenic factor and transforming growth factor (TGF)-β activity regulator, has been recently recognized as an adipokine that correlates with obesity, inflammation and insulin resistance processes. In the present study, epididymal adipocytes of rats that were fed a chow or a high-fat ...

journal_title：Journal of physiology and biochemistry

authors： Garcia-Diaz DF,Arellano AV,Milagro FI,Moreno-Aliaga MJ,Portillo MP,Martinez JA,Campion J

更新日期：2011-09-01 00:00:00

abstract：:Currently, there are no reports in the literature demonstrating any animal model that ingests one of the fattiest animal food source, the bovine brain. We hypothesized that a high-fat diet (HFD), based on dried bovine brain, could be used to develop an animal model possessing a spectrum of insulin resistance-related f...

journal_title：Journal of physiology and biochemistry

authors： Araújo TG,Leite AC,Martins da Fonseca CS,Carvalho BM,Schuler AR,Lima VL

更新日期：2011-09-01 00:00:00

abstract：:The weight loss observed in consumers of extracts of Citrus aurantium (bitter orange) has been tentatively attributed to the lipolytic and thermogenic effects of the alkaloids abundant in the unripe fruit. Synephrine, octopamine, tyramine, and other alkaloids have been repeatedly identified and quantified in Citrus me...

journal_title：Journal of physiology and biochemistry

authors： Mercader J,Wanecq E,Chen J,Carpéné C

更新日期：2011-09-01 00:00:00

abstract：:Lipoic acid (LA) is an antioxidant with therapeutic properties on several diseases like diabetes and obesity. Apelin is a novel adipokine with potential beneficial actions on glucose metabolism and insulin resistance. The aim of this study was to examine in 3T3-L1 adipocytes the effects of LA on apelin gene expression...

journal_title：Journal of physiology and biochemistry

authors： Fernández-Galilea M,Pérez-Matute P,Prieto-Hontoria P,Martínez JA,Moreno-Aliaga MJ

更新日期：2011-09-01 00:00:00

abstract：:Hearts from subjects with different ages have different Ca(2+) signaling. Release of Ca(2+) from intracellular stores in response to an action potential initiates cardiac contraction. Both depolarization-stimulated and spontaneous Ca(2+) releases, Ca(2+) transients and Ca(2+) sparks, demonstrate the main events of exc...

journal_title：Journal of physiology and biochemistry

authors： Kandilci HB,Tuncay E,Zeydanli EN,Sozmen NN,Turan B

更新日期：2011-09-01 00:00:00

abstract：:The human body is made of some 250 different cell types. From them, only a small subset of cell types is able to produce histamine. They include some neurons, enterochromaffin-like cells, gastrin-containing cells, mast cells, basophils, and monocytes/macrophages, among others. In spite of the reduced number of these h...

journal_title：Journal of physiology and biochemistry

authors： Melgarejo E,Medina MA,Sánchez-Jiménez F,Urdiales JL

更新日期：2010-09-01 00:00:00

abstract：:Previous studies with different results have suggested that total and bioavailable testosterone levels are modified by physical exercise. Such changes may be related to modifications in cortisol levels and could be reflected in some urine androgens. To determine how weight lifting training may affect serum and urinary...

journal_title：Journal of physiology and biochemistry

authors： Maynar M,Timon R,González A,Olcina G,Toribio F,Maynar JI,Caballero MJ

更新日期：2010-06-01 00:00:00

abstract：:In spite of a wide range of drugs being available in the market, treatment of arterial hypertension still remains a challenge, and new therapeutic strategies could be developed in order to improve the rate of success in controlling this disease. Since oxidative stress has gained importance in the last few years as one...

journal_title：Journal of physiology and biochemistry

authors： Mate A,Miguel-Carrasco JL,Monserrat MT,Vázquez CM

更新日期：2010-06-01 00:00:00

abstract：:Although the human homologue of SND p102, p100 coactivator, was initially described as a nuclear protein, the p100 coactivator protein family members have non-nuclear localization in mammalian cells with active lipid handling, storage, and secretion. However, their role in lipid homeostasis remains unresolved. Here, w...

journal_title：Journal of physiology and biochemistry

authors： Garcia-Arcos I,Rueda Y,González-Kother P,Palacios L,Ochoa B,Fresnedo O

更新日期：2010-03-01 00:00:00

abstract：:In order to evaluate the expression of nuclear receptors at the peripheral level in obese subjects, messenger RNA (mRNA) levels of different isoforms of retinoic acid receptor (RAR), triiodothyronine (TR), and peroxisome proliferator-activated receptor (PPAR) were determined and compared in peripheral mononuclear bloo...

journal_title：Journal of physiology and biochemistry

authors： Bairras C,Redonnet A,Dabadie H,Gin H,Atgie C,Pallet V,Higueret P,Noël-Suberville C

更新日期：2010-03-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-G is an immunomodulatory molecule discovered for the first time in the maternal-fetal interface. In cancer context, where high number of natural killer (NK) cells is described, the presence of HLA-G in its soluble form is thought to be essential for NK cells signaling. To evaluate intrace...

journal_title：Journal of physiology and biochemistry

authors： Zidi I,Guillard C,Carosella ED,Moreau P

更新日期：2010-03-01 00:00:00

abstract：:This study was designed to investigate effects of raloxifene (RLX) and estradiol on bone formation and resorption in intact and ovariectomized (ovx) rat models. In the intact model, a total of 24 adult female rats were divided into three groups: Controls subcutaneously received saline alone. RLX (2 mg/kg) and estradio...

journal_title：Journal of physiology and biochemistry

authors： Canpolat S,Tug N,Seyran AD,Kumru S,Yilmaz B

更新日期：2010-03-01 00:00:00

abstract：:Recently resveratrol, a compound naturally occurring in various plants, has been proposed as a potential anti-obesity compound. The aim of the present work was to analyse the effects of different doses of resveratrol on body fat and serum parameters in rats. Thirty-two male Sprague-Dawley rats were randomly divided in...

journal_title：Journal of physiology and biochemistry

authors： Macarulla MT,Alberdi G,Gómez S,Tueros I,Bald C,Rodríguez VM,Martínez JA,Portillo MP

更新日期：2009-12-01 00:00:00

abstract：:Although pigs are adapted to starch-rich diets and have high turnover rates of glucose, very scarce information is available on the molecular basis of glucose transport. Therefore, the present study attempted a systematic screening for the presence of mRNA of glucose transport proteins in main organs of glucose absorp...

journal_title：Journal of physiology and biochemistry

authors： Aschenbach JR,Steglich K,Gäbel G,Honscha KU

更新日期：2009-09-01 00:00:00

abstract：:Isoflavones are a group of natural phytoestrogens including the compound genistein. Health beneficial effects have been attributed to the consumption of this compound, but the fact that it has estrogen-like activity has raised doubts regarding its potential risk in infants, newborns, or in the fetus and placenta durin...

journal_title：Journal of physiology and biochemistry

authors： Speroni F,Rebolledo A,Salemme S,Roldán-Palomo R,Rimorini L,Añón MC,Spinillo A,Tanzi F,Milesi V

更新日期：2009-06-01 00:00:00

abstract：:Several studies have suggested that oxidative stress might cause and aggravate the inflammatory state associated with obesity and could be the link between excessive weight gain and its related disorders such as insulin resistance and cardiovascular diseases. Thus, antioxidant treatment has been proposed as a therapy ...

journal_title：Journal of physiology and biochemistry

authors： Prieto-Hontoria PL,Pérez-Matute P,Fernández-Galilea M,Barber A,Martínez JA,Moreno-Aliaga MJ

更新日期：2009-03-01 00:00:00

abstract：:Analysis of the posttranslational modification of proteins, such as phosphorylation, might yield misleading results due to the presence of other proteins with similar electrophoretic properties that coimmunoprecipitate with the target protein. The aim of the present work was to develop a reliable, easy and economical ...

journal_title：Journal of physiology and biochemistry

authors： Redondo PC,Rosado JA,Salido GM,Sage SO

更新日期：2008-09-01 00:00:00

abstract：:The study investigates the effect of weight-maintaining high-sucrose (HSD) and high-fat (HFD) diets on plasma glucose and insulin concentrations in lean and obese women, and verifies the correlation between insulin profile and body composition. Lean (G1 group, n=6, BMI= 21.4 (20.2-22.8) kg/m2) and overweight/obese (G2...

journal_title：Journal of physiology and biochemistry

authors： Volp AC,Hermsdorff HH,Bressan J

更新日期：2008-06-01 00:00:00

abstract：:While carnitine overload appears to have therapeutic effects in pathological situations such as heart recovery after ischemia, its benefits as dietary supplementation for aerobic exercise have been questioned. We studied the effect of carnitine supplementation on the response of perfused rat heart to ischemia and repe...

journal_title：Journal of physiology and biochemistry

authors： Díaz R,Lorita J,Soley M,Ramírez I

更新日期：2008-03-01 00:00:00

abstract：:The purpose of this study was to apply the new approach for Metabolic Individual Risk-factor And Clustering Estimation (MIRACLE) score in a group of Spanish obese children and adolescents and to describe its relationship with other metabolic risk factors. 153 children with simple obesity were studied: 79 males and 74 ...

journal_title：Journal of physiology and biochemistry

authors： Bueno G,Moreno LA,Bueno O,Morales J,Pérez-Roche T,Garagorri JM,Bueno M

更新日期：2007-12-01 00:00:00

abstract：:Cells are armed with a vast repertoire of antioxidant defence mechanisms to prevent the accumulation of oxidative damage. The cellular adaptive response is an important antioxidant mechanism against physiological and pathophysiological oxidative alterations in a cell's microenvironment. The aim of this paper was to st...

journal_title：Journal of physiology and biochemistry

authors： Mármol F,Sánchez J,López D,Martínez N,Roselló-Catafau J,Mitjavila MT,Puig-Parellada P

更新日期：2007-09-01 00:00:00

abstract：:In order to observe the effects of nicotine on protein expression in rat vascular smooth muscle cells (SMCs), nicotine treated SMCs were studied by proteomic technologies combining two-dimensional electrophoresis (2-DE) and peptide mass fingerprinting (PMF). Real-time RT-PCR was used to validate the differentially exp...

journal_title：Journal of physiology and biochemistry

authors： Wang Z,Wu W,Fang X,Wang Y,Xiao C,Zhao R,Wang L,Qiao Z

更新日期：2007-06-01 00:00:00

abstract：:The objective of the present study was to assess the usefulness and accuracy of different anthropometric measurements in the diagnosis of abdominal visceral obesity in overweight/obese women attending to age and menopausal status. The secondary objective was to evaluate the usefulness of waist circumference (WC) in tw...

journal_title：Journal of physiology and biochemistry

authors： Garaulet M,Hernández-Morante JJ,Tébar FJ,Zamora S

更新日期：2006-12-01 00:00:00